|
|
4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+
|
3.7.1.17
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
|
–
|
| |
BRENDA:
BR49990
KEGG:
R09883
MetaCyc:
RXN-12718
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 4-androstene-3,17-dione + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
| |
BRENDA:
BR362
KEGG:
R08518
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29315;
BS438469
KEGG:
R01838
MetaCyc:
1.1.1.51-RXN;
1.1.1.64-RXN
SABIO-RK:
1917
|
|
|
|
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid
|
1.13.11.25
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
|
–
|
| |
BRENDA:
BR40480
KEGG:
R04597
MetaCyc:
1.13.11.25-RXN
SABIO-RK:
4266
|
|
|
|
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
|
6.2.1.41
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
|
–
|
| |
BRENDA:
BR51067
KEGG:
R10769
MetaCyc:
RXN-12746
|
|
|
|
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
| |
BRENDA:
BS258852
KEGG:
R09884
MetaCyc:
RXN-12714
|
|
|
|
(S)-4-hydroxy-2-oxohexanoate <=> pyruvate + propionaldehyde
|
4.1.3.43
4-hydroxy-2-oxohexanoate aldolase
|
–
|
| |
BRENDA:
BR50714
MetaCyc:
RXN-12735
|
|
|
|
propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+
|
1.2.1.10
acetaldehyde dehydrogenase (acetylating)
1.2.1.27
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57
butanal dehydrogenase
1.2.1.87
propanal dehydrogenase (CoA-propanoylating)
|
–
–
–
–
|
| |
BRENDA:
BR50602
KEGG:
R09097
MetaCyc:
RXN-12736
SABIO-RK:
10853
|
|
|
|
9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
|
0.0.0.0
|
–
|
| |
BRENDA:
BR52868
KEGG:
R09885
MetaCyc:
RXN-12715
|
|
|
|
1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
| |
BRENDA:
BR49974
KEGG:
R09860
MetaCyc:
RXN-12691
|
|
|
|
pregnenolone + NAD+ <=> progesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
| |
BRENDA:
BS383305
KEGG:
R02216
MetaCyc:
RXN-9722
SABIO-RK:
2188
|
|
|
|
cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
BRENDA:
BR29153;
BS386399
KEGG:
R02724
MetaCyc:
1.14.15.6-RXN
SABIO-RK:
2614
|
|
|
|
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN
|
1.14.14.12
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
|
–
|
| |
BRENDA:
BR49866
KEGG:
R09819
MetaCyc:
RXN-12717
|
|
|
|
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29275
KEGG:
R01836
MetaCyc:
1.1.1.51-RXN_WOP;
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
1915
|
|
